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The First Four takes place March 15 and 16, leaving you with the 64 teams who will be in your bracket. They will be divided into four regions - West, Midwest, East, and South. The first round teams have already been decided by the NCAA selection committee. For a list of all participating teams and where they rank, check here.
If you don't have yours yet, here is a printable bracket from CBS Sports with the 64 teams.
In the first round of the tournament, the best teams play the worst teams in each region. For example, the no.1 seed plays the no.16 seed, the no.2 seed plays the no.15 seed, and so on. The March Madness tournament is a single-elimination bracket, so if a team loses, they’re out.
To fill out the bracket, choose which team you think will win in each round and write their name on the next matchup line.
A tip: In the first round, choose at least one no.12 seed team to advance. At least one no.12 seed has advanced in 31 out of the last 36 tournaments. This year, those teams at no.12 are New Mexico State, UAB, Richmond, and then whichever team wins the First Four game between Indiana and Wyoming.
After you’ve filled out the first round, you just repeat the process for the next rounds, writing the names of the teams you think will advance of those you’ve chosen until you get to the final NCAA championship game. In the final, you can make a prediction about the score to break any potential ties within your group.
Another tip: Pick one of the No.1 seeds as your champion. It’s extremely rare that at least one of the No.1 seeds doesn’t make it to the final (it’s happened only twice, ever). In the last nine championships, seven have been won by No.1 seeds | 
